Previous Lists Research Articles

An updated checklist of the amphibians and reptiles of Nayarit, Mexico with conservation status and comparison with adjoining States

Herein, we present an updated list of the species of amphibians and reptiles that inhabit Nayarit, Mexico. In the years since the publication of a previous list in 2016, threats to amphibians and reptiles in Nayarit have continued unabated and efforts to more fully catalogue the richness of Nayarit’s herpetofauna have continued. Nayarit harbours 162 native species of amphibians and reptiles, representing 35 families and 85 genera. These include 37 species of amphibians (35 anurans and two salamanders) and 125 species of reptiles (one crocodile, 44 lizards, 69 snakes and 11 turtles). Of the amphibian and reptile species in Nayarit, 102 are endemic to Mexico and two endemic to Nayarit. The ecoregion with the highest richness of amphibians and reptiles in Nayarit is the Trans-Mexican Volcanic Belt followed closely by the Sierra Madre Occidental and then the Sierra Madre del Sur, the Pacific Lowlands and the Nayarit Islands. Just 5.8% of the species of amphibians and reptiles in Nayarit is IUCN-listed as Vulnerable, Endangered or Critically Endangered, 11.1% are placed in a protected category by SEMARNAT and nearly a third are categorised as high risk by the Environmental Vulnerability Score. The herpetofauna of Nayarit overlaps the most with Jalisco (88.9%). One of the main conclusions of our updated list of the amphibian and reptile species of Nayarit is that our understanding of the full complement of species is not complete, especially the reptiles.

Ants of Kamchatka: checklist, DNA-barcoding and key (Hymenoptera, Formicidae)

Kamchatka is a remote volcanic peninsula in the sub-arctic Far East of Russia. Its myrmecofauna has been scientifically addressed several times. However, previous species lists are contradictory in part and a modern study seems to be lacking. Based on literature review, I conclude that 12 species and 4 genera (Camponotus, Formica, Leptothorax and Myrmica) of ants may be native to Kamchatka. Of those, 9 were found in the field, 3 having a Holarctic, 3 a trans-Palearctic and 3 an East Palearctic distribution. Most species diversity was found at mid-elevations, in pine shrubs and mixed forests, while deciduous forests and open habitats at lower altitudes were surprisingly species poor. DNA-barcoding was performed for 57 specimens/9 species. Genetic diversity (COI) was low for 8/9 species, with the exception of Leptothorax acervorum, for which all samples were of a different haplotype and 2 haplogroups were identified. For the encountered Holarctic and trans-Palearctic species, closely related haplotypes (<0.7% raw distance) occur in Europe and/or North America. Some Formica ants were morphologically atypical, with workers partially resembling those of F. fusca, while gynes identified as F. lemani. Morphometric analysis and DNA-barcoding suggested that all these specimens belong to a single species, F. lemani. Standard images for all specimens and an illustrated key to the worker caste are provided.

Challenges for Future Robotic Sorters of Mixed Industrial Waste: A Survey

To achieve recycling of mixed industrial waste toward an advanced sustainable society, waste sorting automation through robots is crucial and urgent. For this purpose, a robot is required to recognize the category, shape, pose, and condition of different waste items and manipulate them according to the category to be sorted. This survey considers three potential difficulties in the sorting automation: 1) End-effector: to robustly grasp and manipulate different waste items with dirt and deformations; 2) Sensor: to recognize the category, shape, and pose of existing objects to be manipulated and the wet and dirty conditions of their surfaces; and 3) Planner: to generate feasible and efficient sequences and trajectories. This survey includes 76 references to studies related to automatic waste sorting and 159 references to worldwide waste recycling attempts. This pioneering investigation reveals the possibility and limitations of conventional systems; thus, providing insights on open issues and potential technologies to achieve a robot-incorporated sorter for the chaotic mixed waste is one of its contributions. This paper further presents a system design policy for readers and discusses future advanced sorters, thereby contributing to the field of robotics and automation. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Most automated sorting systems operate for limited target waste items. This study is motivated by the automation of mixed industrial waste treatment facilities using advanced robotic sorters. Emerging advances and increasing functionalities of robot system components will widen system applicability and increase use cases in the chaotic mixed industrial waste domain. This paper surveys the research conducted to date, discusses open issues and potential approaches, and presents user guides that provide practitioners with a system design policy. The user guides created according to the strengths and weaknesses of each system configuration provide future researchers and developers with a useful a priori design policy that has been thus far validated on efficiency, quality, productivity, and reliability. A question-and-answer style guide and a sorting-target-aware previous study reference list allows users to find the desired system configuration, including the investigated components according to their purpose.

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

The biological mechanisms of aging drive the development of chronic diseases such as cardiovascular disease, diabetes, dementia, and cancer that dominate our current medical system. Geroscience-guided approaches seek to mitigate these pathological consequences of aging by targeting the fundamental hallmarks of aging. Using modalities that modulate these aging mechanisms to reinforce longevity we can prevent the onset of these diseases as well as target many of them at once. In this way, geroscience-guided approaches hope to extend both lifespan and healthspan in the near future. This article builds upon a previous paper which proposed a standardized process for evaluating FDA-approved medications for their geroscience potential and prioritized them to reflect preclinical and clinical evidence. In this article, we provide an update of the previous list of candidate gerotherapeutics to reflect the new and rapidly evolving evidence. We include the geroscience-guided evidence for three new FDA-approved drugs which did not have strong arguments for inclusion before: bisphosphonates, GLP-1 receptor agonists, beta blockers. This updated prioritization should help guide the efforts and financial investments for translating geroscience and allow immediate progress involving such candidate gerotherapeutics, especially the top 4 drugs: SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 receptor agonists. Since all of these drugs have been approved for safety and used extensively, repurposing them as gerotherapeutics should be considered in older adults.

Assessing the conservation status of mangroves in Rakhine, Myanmar

Abstract Ecosystem degradation is a key challenge that human society faces, as ecosystems provide services that are tied to human well‐being. Particularly, mangrove ecosystems provide important services to communities but are suffering heavy degradation, loss and potential collapse due to anthropogenic activities. The IUCN Red List of Ecosystems is a transparent and consistent framework for assessing ecosystems' risk of collapse and is increasingly used to inform legislation and ecosystem management globally. Satellite data have become increasingly common in environmental monitoring due to their extensive spatial and temporal coverage. Here, recent advances in analyses using satellite‐derived data were implemented to reassess the conservation status of the ‘Rakhine mangrove forest on mud’, an important intertidal ecosystem in Myanmar, extending a previous national Red List assessment that assessed the ecosystem as Critically Endangered. By incorporating additional data sources and analyses, the extended assessment produced more robust results and reduced the uncertainty in the previous assessment. Overall, the ecosystem was assessed as Critically Endangered (range: Vulnerable to Critically Endangered) as a result of historical mangrove extent loss. Recent losses and biotic disruptions were also observed, which would have led to the ecosystem being assessed as Vulnerable. While the final outcome of the Red List assessment remained at Critically Endangered due to the historical state of the mangroves pre‐dating the temporal coverage from satellite data, the uncertainty of the ecosystem's status was reduced, and the reassessment highlighted the recent areal changes and mangrove degradation that has occurred. The importance of conducting reassessments when new data become available is discussed, and a template for future mangrove Red List assessments that use satellite data as their primary source of information to improve the robustness of their results is presented.

Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families.

Based on a combination of intensive literature review, electronic database searches, re-identification of museum specimens, and fieldwork, we provide an updated checklist of the continental fishes of Nicaragua. This checklist, systematically arranged at the ordinal and familial level, includes nomenclatural revisions, distributional information, conservation status, and when appropriate, cross-references to previous lists and revisionary works on the fish fauna of the country and region (Central America); illustrations and descriptions to the family level and color photographs of some representative species are also included. According to our results, the native Nicaraguan continental fish fauna is composed of 244 species, divided into 111 genera, 45 families, 24 orders, and two classes; increasing by 60 (i.e., 32.6%) the number of species originally reported by Villa (1982; i.e., the most comprehensive work published to date). The majority of the Nicaraguan native continental fish species, according to their supposed tolerance to salinity, are peripheral (68.9%), followed by secondary freshwater fishes (23.8%), and primary freshwater fishes (only 7.4%). Fish diversity in the 19 major river basins ranged between 21 and 90 species (mean = 58 species, median = 60); the Escondido (Es; 87 species), in the Atlantic, and the Pacfico de Nicaragua (PN; 90), in the Pacific, presented the highest species richness. Most species (188) are restricted to elevations between 0 and 100 meters above sea level (masl); only a few species (18), in contrast, were found at elevations greater than 500 masl (up to 780 masl). Fourteen species in this revision are listed as endemic to Nicaragua. Regarding their conservation status, 22 species (9.0%) are categorized, according to the International Union for Conservation of Nature (IUCN), as Data Deficient, 186 (76.2%) as Least Concern, and seven (2.9%) as Near Threatened; while 24 species (9.8%) are listed as Threatened, thirteen (5.3%) as Vulnerable, two (0.8%) as Endangered, and nine (3.7%) as Critically Endangered. Five species (2.0%) have not yet been evaluated. Six exotic species are also reported. Our results provide a framework for future taxonomic and biogeographic works on fishes from this country and region (Central America), particularly by providing up-to-date knowledge on nomenclature and distributions. In addition, the data provided in this revision will help to monitor fish distributional changes in the future due to human introductions and global change and will aid in conservation decisions concerning Nicaraguan continental fishes.

Conditional versus non-conditional incentives to maximise return of participant completed questionnaires in clinical trials: a cluster randomised study within a trial

BackgroundHigh participant retention enhances the validity of clinical trials. A monetary incentive can increase retention, but it is not known if when it is provided and if it is conditional matters. We aimed to determine whether there was a difference in the number of follow-up trial questionnaires returned when a monetary (gift voucher) incentive was given to participants at recruitment (non-conditional), compared to informing participants at recruitment that the incentive would be given only once their 14-day daily diary (questionnaire) had been returned (conditional).MethodA cluster randomised study within a trial embedded within the Antivirals for influenza-Like Illness, An rCt of Clinical and Cost effectiveness in primary CarE (ALIC4E) Trial. Matched site pairs (GP practices) were randomised using computer-generated random numbers, to either a non-conditional or conditional monetary voucher incentive (only once their 14-day daily diary (questionnaire) had been returned. Sites were matched on previous recruitment levels and practice list size. Analyses were conducted according to randomised groups irrespective of compliance with a two-sided 5% level statistical significance level. The main analysis of the primary outcome (site proportion of diaries returned) was linear regression accounting for site pair (using cluster-robust variance). Additional weighted, paired and non-parametric sensitivity analyses were conducted. Secondary outcomes were the site average number of completed pages, time to return diary, and cost related to the incentive (administration and postage).ResultsOf the 42 randomised sites (21 for each intervention), only 28 recruited at least one participant with only 10 practice pairs recruiting participants at both constituent sites. Raw diaries return proportions were 0.58 (127/220) and 0.73 (91/125) for non-conditional and conditional incentive groups. Regression analysis adjusted for site pair showed no significant difference in returns, − 0.09, (95% CI, − 0.29, 0.10, p = 0.34); when weighted, there was still no clear difference: 0.15 (95% CI, − 0.02, 0.31, p = 0.07). There was no clear statistical evidence of a difference in time taken to return questionnaires, nor the proportion of pages completed, by the intervention group in the main analyses (all p > 0.05). The conditional incentive was approximately £23 cheaper per diary returned based upon observed data.ConclusionThere was no clear evidence of a statistically significant difference in the proportion of participant-completed diaries returned between conditional or non-conditional incentive groups. The time to questionnaire return and completeness of the returned questionnaires were similar in both groups. There was substantial statistical uncertainty in the findings. Some of the sensitivity analyses suggested that a meaningful benefit of a conditional incentive of a magnitude that would be meaningful was plausible. The conditional approach costs less in cash terms.

RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer

Castration-resistant prostate cancer (CRPC) is a big challenge in managing prostate cancer patients. The androgen receptor (AR) pathway is a major driver even in CRPC under androgen deprivation. The mechanism in maintaining of the AR pathway under androgen deprivation remains elusive. The recent discovery of biomolecular condensate, a membrane-less intracellular construct formed by liquid-liquid phase separation (LLPS), that facilitate molecular assembly, encouraged the re-screening of our previous microarray data list. We selected Rbm14 as a target molecule for further analysis because it works as a coactivator of nuclear receptors as well as it facilitates formation of biomolecular condensates via its intrinsically disordered region. GFP-tagged Rbm14 transfected into HEK293T cells formed droplet-like puncta, which diminished following treatment with 1,6-hexanediol. Droplet-like structures were also observed in immunofluorescence for endogenous RBM14 of PC-3 and DU145 cells. Luciferase assay revealed that Rbm14 enhanced androgen-responsive element (ARE)-mediated reporter activity in all conditions with or without testosterone and AR. Co-immunoprecipitation confirmed the Rbm14–AR interaction. Long non-coding RNAs, including NEAT1, SRA1, and HOTAIR, were also interacted with Rbm14. Small interfering RNAs of NEAT1 reduced ARE-mediated reporter activity, while transfection of SRA1 and HOTAIR enhance the reporter activity. Treatment with 1,6-hexanediol as well as transfection with a dominant-negative splice variant of Rbm14 reduced expression of prostate specific antigen (PSA), a prototype of androgen-regulated gene, in LNCaP, PC-3, and DU145 cells under androgen deprivation. Immunohistochemically, RBM14 expression was substantially upregulated in prostate cancer tissues after androgen deprivation therapy than in untreated tumors. In conclusion, RBM14 is a novel factor involved in maintenance of PSA expression via phase separation under androgen deprivation in prostate cancer.

Checklist and molecular phylogenetics reveal three taxonomic novelties in Habenaria (Orchidaceae, Orchidoideae) from Chapada dos Veadeiros, Goiás, Brazil

A comprehensive checklist of Habenaria from Chapada dos Veadeiros, State of Goiás, was performed alongside morphologic and molecular phylogenetic studies, revealing three new taxa endemic to this region. A total of 61 taxa (59 species and two varieties) of Habenaria are recorded for Chapada dos Veadeiros, representing a two-fold increase compared to previous lists and comprising one of the greatest diversities of the genus in Brazil. Of this total, four taxa are locally endemic. Habenaria cultellifolia, until recently known only from the type collection, was rediscovered in the region after 127 years without records and represents this species’ only known extant population. Three proposed new taxa of Habenaria (H. minuticalcar J.A.N. Bat. &amp;#38; Bianch. sp. nov., H. proiteana J.A.N. Bat., A.A. Vale &amp;#38; Bianch. sp. nov., and H. lavrensis var. xanthodactyla J.A.N. Bat. &amp;#38; Bianch. var. nov.) are corroborated by molecular phylogenetic analyses based on nuclear and plastid markers. They are described, illustrated, tentatively assessed as threatened, and compared to phylogenetically and morphologically related species. Since some areas of this mountain range have not yet been floristically sampled, additional taxonomic novelties and new records are still expected in the future.

Taxonomic revision and additional comments of some bats (Mammalia, Chiroptera) reported from Bolivia, with an updated checklist based on voucher material with verified identities

We review the taxonomic identities of museum specimens of three bat species previously reported from Bolivia. We comment on some erroneously reported taxa, or taxa either not represented by voucher materials or based on insufficient data (including acoustic detections) to verify their taxonomic affinities. As result of this review, the list of bat species known to occur in Bolivia is updated to eight families and 133 species, unlike the nine families and 146 species of previous lists. Some recommendations for future research and a brief historical revision of bat inventories in the country are included.

Revised checklist and conservation status of the mammals of Costa Rica

Mammal diversity in Costa Rica is considerably high given the size of the country (51,100 km2), and has increased in recent years.  Taxonomic changes together with distribution extension records have contributed to such an increase.  Here we present the revised and updated list of mammals confirmed for Costa Rica based on previous lists and recent additions obtained from literature, with notes on endemism and conservation status.  This updated list was based on Rodríguez-Herrera et al. (2014a) list, compared and matched with the most updated taxonomic review.  A total of 256 mammals are now confirmed for Costa Rica, with the order Chiroptera and Rodentia as the most representative.  We report 30 endemics for Costa Rica, including those species whose distribution is limited to the country and one of its two neighboring countries, from which 21 are rodents.  Compilation on conservation status information reveals 29.6 % of species within the list classified as threatened, either by Costa Rican or international environmental authorities.  Increase in new studies on mammals all around the world is leading to the discovery of new species.  While systematic and phylogenetic revisions is revealing new taxonomic relationships, and cryptic species.  Mainly on highly diverse and taxonomically challenging groups, as bats, rodents, and shrews, as we evidence here.  Several threatened and endemic species occur in Costa Rica, where the greatest endemism area is the high elevations, and most endemic species are mice.  The creation and establishment of protected areas in a large part of the Costa Rican territory has favored the prevalence of a diverse mammalian assemblage. 

Improving the Well-being of Adolescents With Type 1 Diabetes During the COVID-19 Pandemic: Qualitative Study Exploring Acceptability and Clinical Usability of a Self-compassion Chatbot

Before the COVID-19 pandemic, adolescents with type 1 diabetes (T1D) had already experienced far greater rates of psychological distress than their peers. With the pandemic further challenging mental health and increasing the barriers to maintaining optimal diabetes self-management, it is vital that this population has access to remotely deliverable, evidence-based interventions to improve psychological and diabetes outcomes. Chatbots, defined as digital conversational agents, offer these unique advantages, as well as the ability to engage in empathetic and personalized conversations 24-7. Building on previous work developing a self-compassion program for adolescents with T1D, a self-compassion chatbot (COMPASS) was developed for adolescents with T1D to address these concerns. However, the acceptability and potential clinical usability of a chatbot to deliver self-compassion coping tools to adolescents with T1D remained unknown. This qualitative study was designed to evaluate the acceptability and potential clinical utility of COMPASS among adolescents aged 12 to 16 years with T1D and diabetes health care professionals. Potential adolescent participants were recruited from previous participant lists, and on the web and in-clinic study flyers, whereas health care professionals were recruited via clinic emails and from diabetes research special interest groups. Qualitative Zoom (Zoom Video Communications, Inc) interviews exploring views on COMPASS were conducted with 19 adolescents (in 4 focus groups) and 11 diabetes health care professionals (in 2 focus groups and 6 individual interviews) from March 2022 to April 2022. Transcripts were analyzed using directed content analysis to examine the features and content of greatest importance to both groups. Adolescents were broadly representative of the youth population living with T1D in Aotearoa (11/19, 58% female; 13/19, 68% Aotearoa New Zealand European; and 2/19, 11% Māori). Health care professionals represented a range of disciplines, including diabetes nurse specialists (3/11, 27%), health psychologists (3/11, 27%), dieticians (3/11, 27%), and endocrinologists (2/11, 18%). The findings offer insight into what adolescents with T1D and their health care professionals see as the shared advantages of COMPASS and desired future additions, such as personalization (mentioned by all 19 adolescents), self-management support (mentioned by 13/19, 68% of adolescents), clinical utility (mentioned by all 11 health care professionals), and breadth and flexibility of tools (mentioned by 10/11, 91% of health care professionals). Early data suggest that COMPASS is acceptable, is relevant to common difficulties, and has clinical utility during the COVID-19 pandemic. However, shared desired features among both groups, including problem-solving and integration with diabetes technology to support self-management; creating a safe peer-to-peer sense of community; and broadening the representation of cultures, lived experience stories, and diabetes challenges, could further improve the potential of the chatbot. On the basis of these findings, COMPASS is currently being improved to be tested in a feasibility study.

An Operational Checklist of the Birds of Northwestern Italy (Piedmont and Aosta Valley)

This paper provides the fourth edition of the checklist of birds recorded in northwestern Italy (the Piedmont and Aosta Valley regions) and covers more than 300 years of ornithological data, including subspecies. This work updates the previous works published in 1981, 2003, and 2009, with the revision of the AERC codes and the addition of special annotations for several species. We also provide some new settings to make the bird checklist a more useful tool for all users, particularly scholars and professionals interested in biodiversity assessment and conservation reports. To this end, (a) new coding concerning population estimates and trends, as well as risk categories (Red List), is introduced; (b) bird lists are structured for analysis at two temporal levels: the General Checklist (GCL), covering the period from 1685 to 2022, and the Operational Checklist (OCL), covering the decade 2010–2019, providing periods of reference for comparison and analysis; and (c) an electronic spreadsheet is provided as part of the online Supplementary Materials to allow for further data analysis by readers, if necessary. The list presently contains 408 species and 444 taxonomic units, which consist of both subspecies and monotypic species. Each of them has been allocated to one of the AERC categories A, B, C, or D, while category E has been excluded. Since the publication of the previous list (2009), 19 species have been added. The avifauna currently breeding in the Piedmont and Aosta Valley regions comprises 197 species, with an additional 9 species that were once breeders but are now considered regionally extinct.

Once Again on ʾbk wdm in Ethiopian Sabaic

In an article published in this journal in 2010, Norbert Nebes argued that ʾbk wdm is an apotropaic formula, which can be translated, for instance in the case of RIÉ 9, as ‘und Waddum ist dein (göttlicher) Vater als Schutz vor einem Widersacher’ (wʾbk wdm [b]n ʿtkm). In contrast, it is proposed here that ʾbk wdm continues the previous list of deity names, as already suggested in 1976 by Roger Schneider. Key to this argument is the distribution of the concluding prepositional phrases bn kl mrʿm, ‘from everyone who is malicious’, and bn ʿtkm, ‘from an adversary’, which only occur in inscriptions that have b-s¹qt, ‘by the protection of’. Thus, the following formula is proposed: b-s¹qt DN(s) bn X, ‘by the protection of divine name(s) from X’.

Supplier Selection in Family Small and Medium Enterprises

Current literature on family businesses and small and medium enterprises (SMEs) offers some disintegrated insights in view of managing supply chains, particularly the supplier selection agenda. The presence of distinct characteristics inherent to both enterprises calls for a new line of inquiry regarding supplier selection for family SMEs. This work advances the literature by (1) identifying a set of supplier selection attributes best encapsulating the interests of family SMEs, and (2) evaluating these attributes to guide relevant decision-making. With a case study in the food industry and previous lists of supplier selection attributes, ten attributes were considered relevant to family SMEs. Applying the hybrid entropy-MARCOS method yields the priority attributes in decreasing order: on-time delivery, total service quality, product quality, productivity, attitude, response to customer requests, problem-solving capacity, payment terms, price, and flexibility. An analysis with other comparable methods suggests high consistency of these findings. Theoretical insights were discussed.

Shell-model Study of Two-neutrino Double-Beta Decay for Z = 40–50 Nuclei and their SSD Properties

In this paper, large-scheme shell-model calculations are carried out for two-neutrino double-beta decay of Z = 40–50 nuclei (94Zr, 96Zr, 98Mo, 104Ru, 108Cd, and 116Cd). Within this region, only the half-lives of nuclei 96Zr and 116Cd are experimentally known. The calculated results agree well with experimental data and we predict the half-lives for the remaining four nuclei. Among them, 94Zr and 104Ru have relatively short half-lives of 4.57 × 1023 and 9.83 × 1023 years, respectively, together with large abundance, and are expected to be detected in the near future. By analyzing the convergence of nuclear matrix elements, special attention is paid to their single-state dominance (SSD) property. Here, a new SSD nucleus, i.e., 94Zr, is found, which is a supplement to the previous SSD nuclei list.

[Update of triggers for detection of adverse drug events in hematologic patients].

The use of triggers for the active search and detection of adverse drug events (ADEs) has been gaining ground within pharmacovigilance services. Thus, the main objective of the study was to propose a new list of triggers to be used in a center specialized in hematology in Rio de Janeiro, Brazil. The update of the list of triggers consisted of revising the current list, with the exclusion and inclusion of new triggers. To verify the performance of the new list of triggers, a cross-sectional study was conducted in which the new triggers were used to investigate the occurrence of ADEs in patients attended in the emergency unit or hospitalized from January to March 2022. For each suspected ADEs, the patient's profile and adverse drug reactions (ADRs) were characterized regarding causality and severity. The performance of the triggers and their ability to capture ADEs were estimated using the following indicators: frequency of the trigger per 100 medical records, frequency of ADEs per 100 records, and positive predictive value (PPV). To evaluate the overall performance of the proposed new list, the PPV was estimated. A total of 374 prescriptions for triggers were identified in 186 medical records. The most efficient in the detection of possible ADEs were: lidocaine, loperamide, bisacodyl, filgrastim and glycerin clyster. The overall PPV of the new suggested list was 48% versus 10% of the previous list. This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.

The world of things in traditional Chinese painting

The relevance of the article. The formation of genre and the principles of genre classification in the art of East Asian countries is one of the least researched problems in the theory and history of art. It is generally accepted that still life appeared in the art of China as a result of the influence of the Euro-pean artistic system. Meanwhile, motifs related to the depiction of elements of the subject environment can be traced in other genres of Chinese painting. In modern artistic practice, still life is considered mainly as an element of academic education, but its creative potential remains little realized. Therefore, the relevance of the research is determined by the needs of both theory and artistic practice.&#x0D; The purpose of the article is to determine the main approaches to the depiction of things, their typological complexes, their role and significance in Chinese classical art.&#x0D; The methodology. In the research we used general scientific and special research methods. In particular, methods of systematization, content analysis and typology were applied; methods of formal, stylistic, semantic, comparative analysis.&#x0D; The results. The article outlines the main approaches to studying the origins of still life as a genre in the Chinese artistic tradition. As a result of the analysis of samples of easel and decorative painting, the main models of the representation of things were revealed, their typology, role and means of representation in the visual and content structure of the works were determined. The semantic aspects of pictorial motifs and their connections with the development of handicrafts, Confucian education, tastes and values of the privileged top of society and the development of collecting, are highlighted.&#x0D; The scientific novelty. For the first time, in the work we touched upon the issue of the formation of still life as a genre and its origins in Chinese painting, highlighted the previous artistic experience of depicting objects of the material environment, defined the main thematic complexes, established their role and significance in classical works.&#x0D; The practical significance. The results of the research can be used in the development of educational courses in the history of art and provide the necessary material both for creative experiments and for the development of various projects in the field of visual arts.&#x0D; Conclusions. The results of the analysis of various materials of fine art allow us to claim that in Chinese classical art, other, different from European, options for the representation of the world of things were formed. Typologically, they are represented by three models: a “portrait” of a thing (a close-up of one object with a careful depicting of form and decoration), a thing as a component of a portrait, a catalogue of things (a decorative composition on the theme “4 treasures of a scientist”, “4 noble arts”, “100 antiquities”). In all models, the depicted objects act as personifications of material and spiritual values of society, a sign of Confucian virtues, and as benevolent symbols. The “100 antiquities” complex, which was formed by XVIII century, combined previous lists of valuable things and became a reflection of craft achievements, educational tradition and awareness of its value, and the development of collecting.

For a Pre-history and Post-history of the Corpus Leidense With a List of the Manuscripts of De natura deorum

The present article examines the Corpus Leidense, the group of eight Ciceronian treatises among which the De natura deorum was also transmitted, focusing on its archetype. The second and longer section contains the first complete list of the 174 identified manuscripts of De natura deorum, with 57 new items added to the 117 already listed by Pease in 1955. The items have been divided into three groups: the first contains the antiquiores, with minimal information; the second contains the remaining witnesses listed by Pease, on which additional data are reported; the third group presents the manuscripts that do not appear in any previous list.

Molecular Pathway-Based Classification of Ectodermal Dysplasias: First Five-Yearly Update.

To keep pace with the rapid advancements in molecular genetics and rare diseases research, we have updated the list of ectodermal dysplasias based on the latest classification approach that was adopted in 2017 by an international panel of experts. For this purpose, we searched the databases PubMed and OMIM for the term "ectodermal dysplasia", referring mainly to changes in the last 5 years. We also tried to obtain information about those diseases on which the last scientific report appeared more than 15 years ago by contacting the authors of the most recent publication. A group of experts, composed of researchers who attended the 8th International Conference on Ectodermal Dysplasias and additional members of the previous classification panel, reviewed the proposed amendments and agreed on a final table listing all 49 currently known ectodermal dysplasias for which the molecular genetic basis has been clarified, including 15 new entities. A newly reported ectodermal dysplasia, linked to the gene LRP6, is described here in more detail. These ectodermal dysplasias, in the strict sense, should be distinguished from syndromes with features of ectodermal dysplasia that are related to genes extraneous to the currently known pathways involved in ectodermal development. The latter group consists of 34 syndromes which had been placed on the previous list of ectodermal dysplasias, but most if not all of them could actually be classified elsewhere. This update should streamline the classification of ectodermal dysplasias, provide guidance to the correct diagnosis of rare disease entities, and facilitate the identification of individuals who could benefit from novel treatment options.